Can Lion’s Mane Help With Sleep?

Can Lion’s Mane Help With Sleep?

Can Lion's Mane Help with Sleep? The answer is a promising "maybe."  While research specifically focused on Lion's Mane and sleep is still emerging, this fascinating mushroom has several properties that suggest it could improve sleep quality and help you feel more rested.  

From its potential to reduce anxiety and boost calming brain chemicals to its ability to promote overall brain health, Lion's Mane might be the natural sleep aid you've been looking for.  Let's explore the science behind how this unique mushroom could support a good night's sleep.

The Science Behind Lion's Mane and Sleep

While dedicated research specifically focusing on Lion's Mane and sleep is still in its early stages, there are several ways in which this unique mushroom could potentially influence our sleep patterns:

  • Influencing Brain Chemicals: Lion's Mane might interact with neurotransmitters, the chemical messengers in our brains. It could affect GABA, which has a calming effect, and serotonin, which plays a role in the production of melatonin, our sleep hormone.
  • Boosting Nerve Growth Factor (NGF): Lion's Mane has been shown to stimulate the production of NGF, a protein essential for the development and maintenance of healthy brain cells. This could contribute to stable sleep-wake cycles and improve overall brain function.
  • Fighting Stress and Inflammation: Both stress and inflammation can seriously disrupt sleep. Lion's Mane boasts antioxidant and anti-inflammatory properties that could reduce stress levels and create a more conducive environment for restful sleep.

The Study: Potential Benefits and Limitations

Study Overview

In the study we're examining, participants with overweight or obesity followed a low-calorie diet and took a Lion's Mane supplement. Results suggest that the mushroom could improve sleep quality and even influence levels of BDNF (Brain-Derived Neurotrophic Factor), a protein linked to brain health. It's important to note, however, that this study had a small number of participants and wasn't specifically designed to isolate the effects of Lion's Mane on sleep.


  • BDNF and Sleep: The link between BDNF and sleep is complex, and findings in this area can be mixed. This study offers an intriguing piece of the puzzle, but more research is needed to completely understand how these factors interact.
  • Indirect Benefits: Interestingly, the study also points to Lion's Mane improving mood and reducing anxiety, which in itself could lead to better sleep. We know that stress and mental health issues can significantly affect our sleep patterns.



Improved sleep quality

Better sleep quality could be due to Lion's Mane's influence on neurotransmitters or its anti-stress and anti-inflammatory properties.

Increased BDNF levels

BDNF is involved in brain health and function, and healthy brain function may contribute to better sleep regulation.

Could Lion's Mane Be a Natural Sleep Aid?

Dosage and Safety

The study and other research suggest that Lion's Mane is generally safe, but it's always wise to consult your doctor before starting any new supplement, especially if you have health conditions or take medication.

Clinical studies with Lion's Mane mushroom have used dosages between 1050–3000 mg daily, often split into three or four doses throughout the day. However, the ideal dose is still being determined. The best dosage for you might depend on the specific benefits you're seeking.


Who Might Benefit

Lion's Mane could be particularly helpful for those whose sleep issues are linked to stress, anxiety, or mild cognitive difficulties. Its potential calming effects, support for brain health, and mood-boosting properties could all contribute to better sleep.


Combining with Good Sleep Habits

It's essential to remember that Lion's Mane would likely work best alongside healthy sleep practices. This means a consistent sleep schedule, a relaxing bedtime routine, and a sleep-friendly environment. Think of Lion's Mane as a potential tool in your sleep toolkit, not a magic fix.

Important Considerations

  • More Research is Needed: While the results presented in this study are promising, we need larger studies specifically investigating Lion's Mane and sleep to confirm its benefits and determine how best to use it for improving sleep quality. This is especially important for different populations who may experience various types of sleep difficulties.
  • Individual Response: It's important to remember that not everyone will react to Lion's Mane in the same way. While some people might see significant improvements in their sleep patterns, others may experience little to no change.

Lion's Mane for Sleep Success

  • Take it in the morning: For optimal sleep benefits, take your Lion's Mane supplement earlier in the day. Its potential stimulating effects on brain function could interfere with falling asleep if taken too close to bedtime.
  • Combine with good sleep habits: Lion's Mane works best alongside a healthy sleep routine. This includes:
    • A consistent sleep schedule (same bedtime and wake-up time, even on weekends)
    • A relaxing bedtime ritual (reading, warm bath, etc.)
    • A dark, quiet, and cool sleep environment
  • Manage stress: Techniques like mindfulness, yoga, or spending time in nature can help reduce stress levels and prepare your mind and body for sleep alongside Lion's Mane.

The Takeaways for Using Lion’s Mane for Restful Sleep

The evidence suggests that Lion's Mane has the potential to improve sleep, especially for those whose sleep troubles are linked to stress or anxiety. While more research is needed, its safety profile and potential to support overall brain health make it a promising avenue to explore. If you're struggling with sleep, discuss Lion's Mane with your doctor alongside establishing healthy sleep habits.  It might just be the natural support you were looking for.

If you're interested in exploring the potential sleep benefits of Lion's Mane, consider trying a high-quality, GMO-free, and sustainably sourced supplement.  Mushroom Works' "Cognition" is a great option, offering a potent dose of Lion's Mane to support overall brain health and potentially improve your sleep

Quality and Trust: The Mushroom Works Difference

Finding reputable Lion’s Mane supplements can be a challenge in a market with varying regulations. At Mushroom Works, we understand the importance of quality and transparency. That's why:

  • UK-Based Manufacturing: All of our products are manufactured in the UK to GMP standard, guaranteeing consistent high quality and safety.
  • In-House Expertise: Our supplier uses an in-house regulatory team to ensure any products we make are fully compliant, giving you complete peace of mind.

Choosing Mushroom Works means choosing a brand committed to providing the best possible supplements to support your health journey.

Studies & References

*Luisella Vigna, Federica Morelli, Gianna M. Agnelli, Filomena Napolitano, Daniela Ratto, Alessandra Occhinegro, Carmine Di Iorio, Elena Savino, Carolina Girometta, Federico Brandalise, Paola Rossi, "Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?", Evidence-Based Complementary and Alternative Medicine, vol. 2019, Article ID 7861297, 12 pages, 2019.


  1. Can Lion's Mane replace my sleep medication?

No, Lion's Mane should not be considered a replacement for prescribed sleep medication. If you have a diagnosed sleep disorder, it's wise to consult with your doctor before making any changes to your treatment plan.  Lion's Mane might be a helpful addition alongside medication or for those with milder sleep troubles.

  1. How long does it take for Lion's Mane to start improving sleep?

While some people might notice subtle improvements within the first few weeks, the benefits of Lion's Mane are generally cumulative. Expect to see more noticeable results after a month or more of consistent use.

  1. Are there any specific sleep problems that Lion's Mane might be best for?

Lion's Mane seems particularly promising for sleep troubles linked to stress, anxiety, or mild cognitive difficulties.  Its calming effects and potential for brain support could help create conditions more favourable for restful sleep.

  1. Is Lion's Mane safe to take with other supplements or medications?

It's always best to consult your doctor before combining Lion's Mane with any other supplements or medications.  This is especially important if you take blood thinners or medications for diabetes, as potential interactions could occur.

  1. Where can I find high-quality Lion's Mane supplements?

Look for reputable brands that use sustainably sourced Lion's Mane and offer transparent information about their extraction methods and product purity.  Choose supplements with clear dosage instructions.

References & Studies 

  1. ^Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida TImproving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trialPhytother Res.(2009 Mar)
  2. ^I-Chen Li, Han-Hsin Chang, Chuan-Han Lin, Wan-Ping Chen, Tsung-Han Lu, Li-Ya Lee, Yu-Wen Chen, Yen-Po Chen, Chin-Chu Chen, David Pei-Cheng LinPrevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled StudyFront Aging Neurosci.(2020 Jun 3)
  3. ^Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki KImprovement of cognitive functions by oral intake of Hericium erinaceus.Biomed Res.(2019)
  4. ^Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki KReduction of depression and anxiety by 4 weeks Hericium erinaceus intakeBiomed Res.(2010 Aug)
  5. ^Thongbai et alHericium erinaceus, an amazing medicinal mushroomMycol Progress.(2015-09-16)
  6. ^Jiang S, Wang S, Sun Y, Zhang QMedicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals.Appl Microbiol Biotechnol.(2014-Sep)
  7. ^Vigna L, Morelli F, Agnelli GM, Napolitano F, Ratto D, Occhinegro A, Di Iorio C, Savino E, Girometta C, Brandalise F, Rossi PImproves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?Evid Based Complement Alternat Med.(2019)
  8. ^Chong PS, Fung ML, Wong KH, Lim LWTherapeutic Potential of for Depressive Disorder.Int J Mol Sci.(2019-Dec-25)
  9. ^Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, Nakahata NNerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells.Biol Pharm Bull.(2008-Sep)
  10. ^Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GGThe influence of Hericium erinaceus extract on myelination process in vitro.Fiziol Zh (1994).(2003)
  11. ^Łysakowska P, Sobota A, Wirkijowska AMedicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review.Molecules.(2023-Jul-14)
  12. ^Grozier CD, Alves VA, Killen LG, Simpson JD, O'Neal EK, Waldman HSFour Weeks of Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition.Int J Exerc Sci.(2022)
  13. ^Abdulla MA, Fard AA, Sabaratnam V, Wong KH, Kuppusamy UR, Abdullah N, Ismail SPotential activity of aqueous extract of culinary-medicinal Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats.Int J Med Mushrooms.(2011)
  14. ^Hiwatashi K, Kosaka Y, Suzuki N, Hata K, Mukaiyama T, Sakamoto K, Shirakawa H, Komai MYamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet.Biosci Biotechnol Biochem.(2010)
  15. ^Yang BK, Park JB, Song CHHypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus.Biosci Biotechnol Biochem.(2003-Jun)
  16. ^Ghosh S, Nandi S, Banerjee A, Sarkar S, Chakraborty N, Acharya KProspecting medicinal properties of Lion's mane mushroom.J Food Biochem.(2021-Jun-24)
  17. ^Joseph M Rootman, Maggie Kiraga, Pamela Kryskow, Kalin Harvey, Paul Stamets, Eesmyal Santos-Brault, Kim P C Kuypers, Zach WalshPsilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controlsSci Rep.(2022 Jun 30)
  18. ^Xiao-Qian Xie, Yan Geng, Qijie Guan, Yilin Ren, Lin Guo, Qiqi Lv, Zhen-Ming Lu, Jin-Song Shi, Zheng-Hong XuInfluence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot StudyNutrients.(2021 Mar 21)
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